The Effects of High-Fat Diet on Histological Changes of Kidneys in Rats

Salim, Hotimah Masdan and Kurnia, Lintan Farizqi and Bintarti, Tri Wahyuni and Handayani, . (2018) The Effects of High-Fat Diet on Histological Changes of Kidneys in Rats. Biomolecular and Health Science Journal, 1 (2). pp. 109-112. ISSN 2620-8636

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Official URL: https://e-journal.unair.ac.id/BHSJ/article/view/96...

Abstract

Introduction Hypercholesterolemia contributes as a risk factor for endothelial dysfunction in the kidneys and worsens the condition of patients with previous kidney damage. This study aimed to examine the effect of hypercholesterol diet in kidney structure. Methods: This was an experimental study, a case control using eight-week-old Rattus novergicus, divided into control and treatment group. High-fat diet (HFD) was administrated orally to treatment group for 14 days. All data statistically analyzed with two-paired ANOVA and post hoc for comparison. Results: Histological analysis using hematoxylin-eosin staining showed degeneration in nephrons, including glomerulosclerosis, segmental necrosis and tubular defects. The mononuclear cell infiltration was Increased in HFD group significantly (P<0.05). Conclusion: We concluded that a high fat diet induced obesity and may lead to renal deformities as a result of histopathological changes such as dilatation, tubular defects, inflammation and connective tissue enlargement of the kidney.

Item Type: Article
Uncontrolled Keywords: High-fat-diet; Rattus novergicus; Kidney
Subjects: R Medicine > RC Internal medicine > RC620-627 Nutritional diseases. Deficiency diseases
Divisions: Faculty of Medicine > Program Study of Medicine
Depositing User: Mr. . Aji
Date Deposited: 20 Mar 2019 04:17
Last Modified: 31 May 2019 01:42
URI: http://repository.unusa.ac.id/id/eprint/3829

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