Host Genome Polymorphisms And Tuberculosis Infection: What We Have To Say?

Khalilullah, Said Alfin and Harapan, Harapan and Hasan, Nabeeh A. and Winardi, Wira and Ichsan, Ichsan and Mulyadi, Mulyadi (2014) Host Genome Polymorphisms And Tuberculosis Infection: What We Have To Say? Egyptian Journal of Chest Diseases and Tuberculosis, 63 (1). pp. 173-185. ISSN 0422-7638

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Official URL: https://www.sciencedirect.com/science/article/pii/...

Abstract

Several epidemiology studies suggest that host genetic factors play important roles in susceptibility, protection and progression of tuberculosis infection. Here we have reviewed the implications of some genetic polymorphisms in pathways related to tuberculosis susceptibility, severity and development. Large case-control studies examining single-nucleotide polymorphisms (SNPs) in genes have been performed in tuberculosis patients in some countries. Polymorphisms in natural resistance-associated macrophage protein 1 (NRAMP1), toll-like receptor 2 (TLR2), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), interleukin-1 receptor antagonist (IL-1RA), IL-10, vitamin D receptor (VDR), dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN), monocyte chemoattractant protein-1 (MCP-1), nucleotide oligomerization binding domain 2 (NOD2), interferon-gamma (IFN-γ), inducible nitric oxide synthase (iNOS), mannose-binding lectin (MBL) and surfactant proteins A (SP-A) have been reviewed. These genes have been variably associated with tuberculosis infection and there is strong evidence indicating that host genetic factors play critical roles in tuberculosis susceptibility, severity and development.

Item Type: Article
Uncontrolled Keywords: Mycobacterium tuberculosis, Tuberculosis infection, Gene polymorphism, Tuberculosis susceptibility, Tuberculosis development, Tuberculosis protection
Subjects: R Medicine > RC Internal medicine > RC306-320.5 Tuberculosis
Divisions: Faculty of Medicine > Program Study of Medicine
Depositing User: Mr. . Bagas
Date Deposited: 14 Jun 2020 07:50
Last Modified: 11 May 2023 07:34
URI: http://repository.unusa.ac.id/id/eprint/6092

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