Safri, Mulya and Lubis, Bidasari and Munasir, Zakiudin and Mulyadi, Mulyadi and Mudatsir, Mudatsir and Putra, Aulia R. (2015) Cow’s Milk Protein Sensitization On The Lymphocyte Th-1 And Th-2 Activity In Relation To Wheezing In The First Year Of Life. Human & Veterinary Medicine - International Journal of the Bioflux Society, 7 (1). pp. 31-37. ISSN 2066-7663
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Abstract
Background: Atopic diseases are common and represent a serious heatlh problem worldwide and the incidence was increased in last three decades. Allergic disease is developed by at least three things: the genetic background, exposure to allergens and amplified by environ-mental factors. Wheezing is known as a common symptom in infant. Objective: To find an overview of the role of cow’s milk protein sensi-tization on the lymphocyte Th-1 and Th-2 activity in relation with wheezing in infants up to 1 year of age. Methods: This exploratory obser-vational, cohort study included total 71 infants collected by consecutive sampling. Data were collected from questionnaires completed by the parents, medical records, blood samples and skin prick test examination. Results: A total of 64.8% from 71 subjects suffering from wheezing. Allergy risk factors (95% CI 1.184-2.177; p = 0.007), skin prick test > 3 mm (95% CI 2.073-5.910; p = 0.000), IFN-γ levels below 0.53 (95% CI 1.029-2.046; p = 0.033), IL-5 levels above 0.6 (95% CI 1.685-6.877; p = 0.000), and the father smoked (95% CI 1.168-2.542; p = 0.003) ap-pear related to the occurrence of wheezing. Multivariate test shown, the level of IL-5 (p = 0.000; RR 20.69; 95% CI: 4.51 to 94.83) combined with the level of IFN-γ (p = 0.010; RR 10.28; 95% CI: 1.73 to 31.61) and exposed to tobacco smoke by dad in indoor (p = 0.020; RR 6.49; 95% CI: 1.33 to 31.61), are clinically the trigger factors of wheezing in infants in the first year of life. Conclusion: A significant sensitivity of cow’s milk had happened on this research subject and was marked by the early allergic march baby wheezing friction. Allergy risk in parent and ex-posed to tobacco smoke by dad in indoor are contribute to the onset of wheezing, through the activity of Th-2 lymphocytes are increased so that the level of IL-5 to be higher in infants suffering from atopic wheeze.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | infant atopy, allergy risk factors, cow’s milk sensitization, environmental factors, activity of Th-1 and Th-2. |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Program Study of Medicine |
| Depositing User: | Mr. . Bagas |
| Date Deposited: | 14 Jun 2020 08:17 |
| Last Modified: | 11 May 2023 07:25 |
| URI: | http://repository.unusa.ac.id/id/eprint/6093 |
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