The Correlation Of Age And Body Mass Index With The Level Of Both Protease MMP3 And Anti‑Protease TIMP‑1 Among Indonesian Patients With Chronic Obstructive Pulmonary Disease: A Preliminary Findings

Mulyadi, Mulyadi and Sunnati, Sunnati and Azhary, Mulkan and Yunus, Faisal and Nurwidya, Fariz (2018) The Correlation Of Age And Body Mass Index With The Level Of Both Protease MMP3 And Anti‑Protease TIMP‑1 Among Indonesian Patients With Chronic Obstructive Pulmonary Disease: A Preliminary Findings. BMC Research Notes, 11 (151). pp. 1-4. ISSN 1756-0500

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Abstract

Objectives: Individuals with chronic obstructive pulmonary disease (COPD) are usually > 50 years of age and have a low body mass index (BMI). An imbalance between matrix metalloproteinases (MMPs), including MMP-3, and tissue inhibitor of metalloproteinase 1 (TIMP-1), play a role in tissue degradation of lung extracellular matrix among COPD individuals. The purpose of the present study was to correlate age and/or BMI with salivary levels of MMP-3 and TIMP-1 among Indonesian subjects with COPD. Results: Thirty COPD patients were recruited to undergo thorough physical assessment and saliva collection for evaluating TIMP-1 and MMP-3 levels using commercially available kits enzyme-linked immunosorbent assay method. The mean (standard deviation) participant age and BMI were 60.5 (8.13) years, and 23.1 (4.75) kg/m , respectively. Furthermore, the mean (standard deviation) of TIMP-1 and MMP3 levels were 23.99 (6.85) ng/mL and 1.81 (1.167) μM, respectively. Age was negatively correlated with MMP-3 (P < 0.05), but not with TIMP-1 levels. Age and BMI were not correlated with TIMP-1 level (P > 0.05). Collectively, this study demonstrated that age has a negative correlation with the protease marker (i.e. MMP-3), but not the anti-protease marker (TIMP-1). BMI was not correlated with either protease/anti-protease marker among Indonesian subjects with COPD.

Item Type:	Article
Uncontrolled Keywords:	Age, BMI, Salivary MMP-3, Salivary TIMP-1
Subjects:	R Medicine > RC Internal medicine
Divisions:	Faculty of Medicine > Program Study of Medicine
Depositing User:	Mr. . Bagas
Date Deposited:	14 Jun 2020 10:46
Last Modified:	11 May 2023 07:40
URI:	http://repository.unusa.ac.id/id/eprint/6098

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