Chitosan as Antifungal in Channa striata Collagen Chitosan for Wound Healing

Andini, Ary and Prayekti, Endah (2019) Chitosan as Antifungal in Channa striata Collagen Chitosan for Wound Healing. Medical and Health Science Journal, 3 (2). pp. 8-11. ISSN 2549-7588

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Official URL: https://journal2.unusa.ac.id/index.php/MHSJ/articl...

Abstract

Background: The Snakehead fish (Channa striata) contains high protein that was mostly used for treatment during healing process. It could be developed as well as a mixtured with chitosan for wound dressing. Chitosan known as biodegradability, biocompatibility and bioactivity biopolymers. The aim of this study was to know the effect of combination of concentrations between chitosan and collagen of Snakehead fish skin and scales on fungal total number recovered from the composite. Methods: Snakehead fish skin and scales was treated by soaking in 2% HCl solvent for 48 hours to obtain collagen from its filtrate. Filtrate obtained continued to neutralize with 1 M NaOH until soluble collagen appeared. Collagen obtained in this study then mixed with 2% chitosan liquid to make wound dressing in various concentrations group. Results: Combination of colagen mixture in this study were chitosan liquid only as control, 25% collagen-75% chitosan (C1), 50% collagen-50% chitosan (C2) and 75% collagen-25% chitosan (C3). The study results showed that on Control, C1 and C2 group there was no fungal growth, but on C3 group there was fungal growth with total counting about 2,43 x 103 CFU. Based on statistically test showed that there was discrepancy for each group with p-value was 0,02 (p<0,05). Conclusion: This research showed that chitosan content could contributed as ananti-fungal.

Item Type: Article
Uncontrolled Keywords: Channa striata, collagen, chitosan, fungal, wound
Subjects: R Medicine > RC Internal medicine > RC86-88.9 Medical emergencies. Critical care. Intensive care. First aid
Divisions: Faculty of Health > Program Study of Health Analyst
Depositing User: Mr. . Aji
Date Deposited: 06 Apr 2021 02:16
Last Modified: 06 Apr 2021 02:16
URI: http://repository.unusa.ac.id/id/eprint/6476

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