Bintarti, Tri Wahyuni and Salamy, Nanda Fadhilah Witris and Choirotussanijjah, Choirotussanijjah (2020) Effect of Rosa damascene mill. Extract on blood glucose levels in diabetes model rats (Rattus norvegicus). The 1st International Nursing and Health Sciences Symposium. pp. 60-65. ISSN 978-623-95759-0-8
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Abstract
Diabetes mellitus (DM) is a chronic metabolic disorder caused by a lack or resistance to insulin and is characterized by hyperglycemia in the postprandial and fasting states. Postprandial hyperglycemia can lead to non-enzymatic glycosylation of various proteins, leading to the development of chronic complications. Control of postprandial plasma glucose levels is very important in the initial treatment of DM to reduce chronic vascular complications. This study aims to determine the effect of Rosa damascena extract on blood glucose levels. RDM is obtained from Batu city. A total of 3 kg of rose petals was dried, mashed, soaked with 96% ethanol, filtered, then extracted from the filtration using a rotary evaporator. The study used male wistar rats (Rattus norvegicus) 8-10 weeks old and weighing 150-200 grams. Rats were randomly divided into 6 groups of negative control group (KN), positive control group (KP), metformin group (KM), treatment group 1 (P1) RDM 250 mg / kg body weight, treatment group 2 (P2) RDM 500 mg / kg body weight, treatment group 3 (P3) RDM 1000 mg / kg body weight. Examination of blood glucose using peripheral blood before euthanasia. The Kruskal Wallis test results showed a Sig (P-Value) of 0.030 (p <0.05), which means that there were significant differences in all treatment groups. The results of the Mann Whitney-U test showed that the KN group was significantly different from all groups (Sig P-Value <0, 05) while the KP, KM, P1, P2 and P3 groups had no significant differences with other groups (Sig P-Value > 0.05). The lowest blood glucose level was in the P1 group, the treatment group given STZ and Rosa damascena Mill extract at 250 mg/kg body wt. Meanwhile, the highest blood glucose level was in the KP group, the positive control group that was only given STZ. In conclusion, Rosa damascena Mill extract may have an antidiabetic effect by reducing postprandial blood sugar levels.
| Item Type: | Article |
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| Uncontrolled Keywords: | Diabetes Mellitus, Rosa Damascena Mill, Blood Glucose |
| Subjects: | R Medicine > RC Internal medicine > RC581-951 Specialties of internal medicine |
| Divisions: | Faculty of Medicine > Program Study of Medicine |
| Depositing User: | Mr. . Aji |
| Date Deposited: | 03 May 2021 07:36 |
| Last Modified: | 04 Apr 2024 03:39 |
| URI: | http://repository.unusa.ac.id/id/eprint/6521 |
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