Hepatoprotective Effects of Methanol Extract of Syzygium polyanthum L. Leaves (Salam) on High Fat Diet

Salim, Hotimah Masdan and Kurnia, Lintan Farizqi and Bintarti, Tri Wahyuni and Handayani, . and Shimabukuro, Michio (2021) Hepatoprotective Effects of Methanol Extract of Syzygium polyanthum L. Leaves (Salam) on High Fat Diet. Tropical Journal of Natural Product Research, 5 (12). pp. 2092-2095. ISSN 2616-0692

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Abstract

Dyslipidemia (hyperlipidemia) is a strong risk factor for cardiovascular disease. Syzygium polyanthum (Wight) Walp. var. polyanthum leaves are widely consumed as a traditional Indonesia treatment. The study aimed to investigate the effect of Syzygium polyanthum (Wight) Walp extract in decreasing hypercholesterolemia in Wistar rats. Syzygium polyanthum (Wight) Walp extract (0.72, 0.9 and 1.08 g/day) was administered by gavage to the high fat diet-induced hipercholesterolemia in rats for 2 weeks. The result revealed that the extract administration reduced total cholesterol levels (P<0.05), low-density lipoprotein (LDL) (P<0.05), and triglyceride (TG) (P<0.05) without alteration of body weight. Furthermore, the histological analysis showed that Syzygium polyanthum (Wight) extract decreased lipid accumulation in the liver (p < 0.05). It is concluded that Syzygium polyanthum (Wight) extract significantly lowered total cholesterol and led to lipid accumulation reduction in the liver in hypercholesterolemic Wistar Rat model.

Item Type:	Article
Uncontrolled Keywords:	Hepatoprotective, Hypercholesterolemia, Syzygium polyanthum (Wight), Lipid accumulation
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine > Program Study of Medicine
Depositing User:	Mr. . Aji
Date Deposited:	07 Oct 2022 08:00
Last Modified:	28 Jul 2023 06:04
URI:	http://repository.unusa.ac.id/id/eprint/8932

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