Salim, Hotimah Masdan and Alam, Ilham Putra and Kharisma, Widya Dio (2020) Organ Damage due to Elevation of Blood Pressure on NaCl-induced. Biomolecular and Health Science Journal, 3 (2). pp. 106-108. ISSN 2620-8636
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Abstract
Introduction: High salt diet is known to induce or aggravate hypertension in hypertensive rats and humans. The elevation of blood pressure by NaCl-induced promotes cardiac hypertrophy, the impairment of left ventricular relaxation, endothelial dysfunction, and kidney injury. This study aimed to examine whether NaCl-induced caused increase blood pressure and weight of organs. Methods: Eight weeks old male Mus musculus were divided to two groups, one group was given NaCl 8% by intraperitoneal injection for 8 hours. Results: Blood pressure was measured previously, in this study systolic and diastolic blood pressure increased significantly (p < 0.05). The increasing of blood pressure was followed by significant increase in organ weight, such as heart and kidney (p < 0.05). Conclusion: This result suggested that NaCl-induced caused hypertension and increased organs weight that may cause early process of damages in organs.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NaCl-induce, Hypertension, Organs. |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Faculty of Medicine > Program Study of Medicine |
| Depositing User: | Mr. . Aji |
| Date Deposited: | 12 Dec 2022 03:38 |
| Last Modified: | 12 Dec 2022 03:38 |
| URI: | http://repository.unusa.ac.id/id/eprint/9088 |
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