Efficacy of Ethanol Extract of Water Clover (Marsilea crenata) Leaves on Estradiol Levels in Wistar Rats Post Ovarectomy Skin Aging Model

Devi, Dian Safira and Putri, Winawati Eka and Amalia, Rizki (2023) Efficacy of Ethanol Extract of Water Clover (Marsilea crenata) Leaves on Estradiol Levels in Wistar Rats Post Ovarectomy Skin Aging Model. AIP Conference Proceedings, 2595 (1). ISSN 978-0-7354-1934-6

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Abstract

Oestrogen consists of three hormones, namely estrone, estradiol, and estriol. Decreased estrogen levels can occur in individuals who have pituitary gland disorders, Turner syndrome, and women who have gone through menopause. It causes changes in many-body systems and organs, including the skin. Water clover plants contain bioactive isoflavones of flavonoid glycosides, including genistein and daidzein. Both of which have body activities similar to estrogen. The oestrogenic activity is related to the structure of isoflavones, which can be transformed into equol which has a structure similar to the estrogen hormone. The researchers analyzed the effect of water clover leaf extract (Marsilea crenata) on estradiol levels in post-ovariectomy Wistar rats with skin aging models. The researchers employed the true experimental research with a posttest-only control group design. Five research groups consisted of a control group (K) and a treatment group (P1, P2, P3, and P4). Clover leaves can increase the estradiol level in the blood indicated by the results of the Kruskal-Wallis non-parametric test (p-value of 0.016). Therefore, water clover leaf ethanol extract had a significant effect on estradiol blood levels in post-ovariectomy Wistar rats.

Item Type:	Article
Uncontrolled Keywords:	water clover leaf extract, estradiol, rats, ovariectomy
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine > Program Study of Medicine
Depositing User:	Mr. . Aji
Date Deposited:	07 Jul 2023 03:57
Last Modified:	28 Feb 2024 03:15
URI:	http://repository.unusa.ac.id/id/eprint/9574

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