The Effectiveness of Alpha Mangostin on Kidney Physiology and Histopathology in Type II Diabetes Mellitus

Santoso, Andreas Putro Ragil and Wulandari, Devyana Dyah and Kardina, Rizki Nurmalya and Wulansari, Devyani Dyah and Meidiyanti, Bertha and Proborini, Kintani Nisa (2022) The Effectiveness of Alpha Mangostin on Kidney Physiology and Histopathology in Type II Diabetes Mellitus. Biointerface Research in Applied Chemistry, 12 (6). pp. 8335-8342. ISSN 2069-5837

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Abstract

The compound isolate alpha Mangostin was the most dominant compound found in the rind and trunk of the mangosteen fruit tree (Garcinia mangostana L.). Alpha Mangostin compounds have pharmacological activities, including antibacterial, antifungal, anticancer, antidiabetic, and other bioactivities. This study aims to determine the bioactivity of alpha Mangostin on kidney function and histopathology in type II diabetes mellitus. This study used an experimental research design with posttest only control group; this study used 36 rats consisting of 6 groups, namely negative control group, positive control group, standard medicine, and the treatment of lecturers alpha Mangostin 10 mg/kg body weight, 30 mg/kg body weight, and 50 mg/kg BW. Parameters measured in this study were uric acid, BUN, creatinine, and renal histopathological evaluation. The results showed that there was a significant difference (p < 0.05) in the examination of creatinine levels, but the BUN and uric acid did not show significant results (p > 0.05) in each group. Observations on renal histopathology showed that alpha Mangostin could normalize damaged kidney tissue compared to positive controls. So it can be concluded that alpha Mangostin isolates in mangosteen has the potential as kidney bioactivity in type II diabetes.

Item Type:	Article
Uncontrolled Keywords:	Diabetes; Alpha Mangostin; kidney function, kidney histopathology
Subjects:	R Medicine > RC Internal medicine > RC581-951 Specialties of internal medicine
Divisions:	Faculty of Health > Program Study of Health Analyst
Depositing User:	Mr. . Aji
Date Deposited:	07 Aug 2023 08:48
Last Modified:	08 Sep 2023 09:18
URI:	http://repository.unusa.ac.id/id/eprint/9642

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