The Roles Of MicroRNAs On Tuberculosis Infection: Meaning Or Myth?

Harapan, Harapan and Fitra, Fitra and Ichsan, Ichsan and Mulyadi, Mulyadi and Miotto, Paolo and Hasan, Nabeeh A. and Calado, Marta and Cirillo, Daniela M. (2013) The Roles Of MicroRNAs On Tuberculosis Infection: Meaning Or Myth? Tuberculosis, 93 (6). pp. 596-605. ISSN 1472-9792

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Abstract

The central proteins for protection against tuberculosis are attributed to interferon-γ, tumor necrosis factor-α, interleukin (IL)-6 and IL-1β, while IL-10 primarily suppresses anti-mycobacterial responses. Several studies found alteration of expression profile of genes involved in anti-mycobacterial responses in macrophages and natural killer (NK) cells from active and latent tuberculosis and from tuberculosis and healthy controls. This alteration of cellular composition might be regulated by microRNAs (miRNAs). Albeit only 1% of the genomic transcripts in mammalian cells encode miRNA, they are predicted to control the activity of more than 60% of all protein-coding genes and they have a huge influence in pathogenesis theory, diagnosis and treatment approach to some diseases. Several miRNAs have been found to regulate T cell differentiation and function and have critical role in regulating the innate function of macrophages, dendritic cells and NK cells. Here, we have reviewed the role of miRNAs implicated in tuberculosis infection, especially related to their new roles in the molecular pathology of tuberculosis immunology and as new targets for future tuberculosis diagnostics.

Item Type:	Article
Uncontrolled Keywords:	Mycobacterium tuberculosis, Tuberculosis infection, microRNA, Tuberculosis immunology
Subjects:	R Medicine > RC Internal medicine > RC306-320.5 Tuberculosis
Divisions:	Faculty of Medicine > Program Study of Medicine
Depositing User:	Mr. . Bagas
Date Deposited:	14 Jun 2020 08:57
Last Modified:	11 May 2023 07:33
URI:	http://repository.unusa.ac.id/id/eprint/6095

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