Andini, Ary and HANDAJANI, RETNO and Koesnowidagdo, Soetjipto and Ichsan, Miranda Zawawi and Pighinelli, Luciano (2020) In vivo Effectivity of Collagen Extract from Clarias gariepinus (Burchell, 1822) ‘Sangkuriang’ on Formation of Malondialdehyde and Macrophages in Burn Healing. Proceedings of the Pakistan Academy of Sciences: Pakistan Academy of Sciences B. Life and Environmental Sciences, 57 (3). pp. 35-40. ISSN 2518-427X
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Abstract
Topical collagen on skin wound gift moist state that could stimulate reepithelization, proliferation, and epithelial cell migration to conduct growth factor activity on the wound area. One of the sources of collagen is Sangkuriang catfish [Clarias gariepinus (Burchell, 1822) ‘Sangkuriang’] skin that had low immunoreactivity in the human body. This study aimed to determine the influence of topical treatment with Sangkuriang catfish skin extract on malondialdehyde serum and macrophage total on burn injury. Collagen of Sangkuriang catfish skin was extracted by HCl 2 % for 48 h and neutralized by NaOH 1 M. Sangkuriang catfish skin extract contained amino acid of collagen that could repair and stimulate skin cell. This study was an experimental study that used 24 male Rattus norvegicus strain Wistar were divided into K3, P3, K10, and P10 groups. K group was treated with aquadest topical as a burn healing treatment for 3 d (K3) and 10 d (K10). The P group was treated with topical collagen extract as a burn healing treatment for 3 d (P3) and 10 d (P10). The results showed that treatment by collagen from Sangkuriang catfish skin could not decrease MDA serum on 3 rd d and 10 d because of P > 0.05 (P = 0.713). Furthermore, it could not decrease macrophage total on 3 rd d (P = 0.427) but significantly decrease to 10 d for K10 and P10. Collagen topical from Sangkuriang catfish could accelerate burn to heal by decreasing macrophages total on 10 th d due to P < 0.05 (P = 0.000).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Burn injury, Catfish, Collagen extract, Skin, Wound healing |
| Subjects: | R Medicine > RC Internal medicine > RC86-88.9 Medical emergencies. Critical care. Intensive care. First aid |
| Divisions: | Faculty of Health > Program Study of Health Analyst |
| Depositing User: | Mr. . Aji |
| Date Deposited: | 06 Apr 2021 03:02 |
| Last Modified: | 06 Apr 2021 03:08 |
| URI: | http://repository.unusa.ac.id/id/eprint/6479 |
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