Analysis of The Toxicity Of Bovine Serum Albumin Nanoparticle Based Cancer Drugs

Nidianti, Ersalina and Andini, Ary and Rizka, Rizka (2020) Analysis of The Toxicity Of Bovine Serum Albumin Nanoparticle Based Cancer Drugs. International Confrence on Agromedicine and Medical Sciences (ICAMS) 2020. ISSN 2774-4973

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Abstract

Cancer is a non-communicable disease that causes morbidity and mortality in all regions of the world. Basic Health Research Data on the prevalence of cancer in Indonesia shows an increase from 1.4 per 1,000 population in 2013 to 1.79 per 1,000 population in 2018. Cancer treatment is important in reducing the number of deaths (mortality) due to cancer sufferers. One of the cancer treatments is using the chemotherapy drug cisplatin. Cisplatin given intravenously as a short-term infusion in a saline solution for the treatment of malignant cancer. The administration of cisplatin in clinical cancer treatment is due to its toxic side effects which depend on the drug dose. Purpose: The purpose of this study was to determine the level of toxicity of herbal cancer drugs and cisplatin-based chemotherapy drugs combined with Bovine Serum Albumin (BSA) nanoparticles Research Methodology: This research is an experimental research. Toxicity test was carried out using the Brine Shrimp Lethality Test (BSLT) method with various concentrations of 1 ppm, 10 ppm and 100 ppm, while the controls used ethanola and DMSO Results: Toxicity test used Artemia salina shrimp larvae. The toxic effect was identified by the percentage of mortality of shrimp larvae using probit analysis (LC50). There are three categories, namely toxic, highly toxic, and non-toxic. The toxicity level of the NP-BSA with the LC50 value was 69.23 ppm. The higher the concentration, the higher the resulting toxicity. Limitations: Write a brief limitation of the study Contribution: Where this study can be useful? Give the name ofarea, disciplines, etc.

Item Type:	Article
Uncontrolled Keywords:	Drug toxicity, Cisplatin, BSA Nanoparticles
Subjects:	R Medicine > RC Internal medicine > RC266 Oncology nursing
Divisions:	Faculty of Health > Program Study of Health Analyst
Depositing User:	Mr. . Aji
Date Deposited:	06 Feb 2023 08:39
Last Modified:	29 Aug 2023 07:56
URI:	http://repository.unusa.ac.id/id/eprint/9197

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