Exercise Decrease the Expression of MCP-1 in Perivascular Adipose Tissue (PVAT) in Obese Mice

Salim, Hotimah Masdan and Aisyah, Aisyah and Shimabukuro, Michio (2022) Exercise Decrease the Expression of MCP-1 in Perivascular Adipose Tissue (PVAT) in Obese Mice. Bali Medical Journal, 11 (3). pp. 1126-1129. ISSN 2302-2914

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Abstract

Introduction: Exercise has been believed to prevent metabolic syndrome (Mets) from occurring. Accumulation of inflammation factors such as monocytes chemoattractant protein-1 (MCP1) in adipose tissue is a factor in the development of MetS. However, the inflammatory mediators that play a role in the accumulation of macrophages are still unclear, so this study aims to determine the expression of MCP-1 in perivascular adipose tissue (PVAT). Methods: Eight-week-old male wild-type mice, were divided into five groups. One control group was given a standard diet and four groups were given a high-fat diet (HFD) for 2 weeks. Exercise treatment was given to the HFD group by dividing HFD with exercise once a week, HFD with exercise three times a week, and HFD with exercise five times a week. As for the exercise, speed is given 10-18m/minute for 30 minutes. and this exercise is carried out for two weeks. Gene expression of MCP-1 in PVAT tissues was analyzed using quantitative chain reaction (PCR). Results: The HFD group experienced an increase in body weight (P <0.01) and adipose tissue mass (P <0.01) compared to the control group. Furthermore, exercise decreased body weight (P <0.05) and adipose tissue in the HFD-Exc1 group (P <0.01). Furthermore, exercise tends to decrease the inflammatory mediator in macrophages MCP-1 in PVAT compared to the HFD group. Conclusion: These results suggested that exercise partially reduces adiposity, tended to decreases MCP-1 in HFD-induced obesity.

Item Type:	Article
Uncontrolled Keywords:	HFD; exercise; PVAT; MCP-1
Subjects:	R Medicine > R Medicine (General)
Divisions:	Faculty of Medicine > Program Study of Medicine
Depositing User:	Mr. . Bagas
Date Deposited:	13 Jul 2023 07:32
Last Modified:	13 Jul 2023 07:32
URI:	http://repository.unusa.ac.id/id/eprint/9597

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